The Liverpool and Manchester Railway was the world's first steam powered, inter-urban railway designed to transport both passengers and goods. Its Manchester terminus was Liverpool Road Station, now home to the Science and Industry Museum.

James Joule is now rightly revered as one of the greatest scientists in the history of physics. However, in his younger years, Joule struggled to be taken seriously by the scientific establishment.

John Dalton was a Manchester-based scientist whose pioneering work greatly advanced our understanding in multiple fields of research, including atomic theory, colour blindness and meteorology.